What is lorazepam used for?
Lorazepam is commonly used to treat the following conditions.
Anxiety disorders
A type of seizure called status epilepticus (injection)
Lorazepam may also be used for other conditions as determined by your healthcare provider.
How does lorazepam work (mechanism of action)?
Lorazepam produces a calming effect on the brain and nerves, which helps to reduce anxiety symptoms and treat seizures.
How is lorazepam supplied (dosage forms)?
Brands and other names
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Ativan
Loreev XR
Dosage forms and strengths
1 mg extended-release oral capsules
1.5 mg extended-release oral capsules
2 mg extended-release oral capsules
3 mg extended-release oral capsules
2 mg/mL oral concentrate
0.5 mg oral tablets
1 mg oral tablets
2 mg oral tablets
Lorazepam is also available in injectable forms.
How should I store lorazepam?
Oral Tablets and Extended-Release Oral Capsules. Lorazepam oral tablets and extended-release oral capsules should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.
Oral Concentrate and Injection. Lorazepam oral concentrate and injection should be stored in a refrigerator, between 36 F to 46 F (2 C to 8 C). Protect the medicine from exposure to light.
Side Effects
What are the most common side effects of lorazepam?
The most common side effects of lorazepam are listed below. Tell your healthcare provider if you have any of these side effects that bother you.
Drowsiness (or sleepiness)
Dizziness
Weakness
Trouble with balance or coordination
There may be other side effects of lorazepam that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In copyright, you can report side effects to Health copyright at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of lorazepam?
While less common, the most serious side effects of lorazepam are described below, along with what to do if they happen.
Severe Allergic Reactions. Lorazepam may cause allergic reactions, which can be serious. Stop taking lorazepam and get help right away if you have any of the following symptoms of a serious allergic reaction.
Breathing problems or wheezing
Racing heart
Fever or general ill feeling
Swollen lymph nodes
Swelling of the face, lips, mouth, tongue, or throat
Trouble swallowing or throat tightness
Itching, skin rash, or pale red bumps on the skin called hives
Nausea or vomiting
Dizziness, feeling lightheaded, or fainting
Stomach cramps
Joint pain
Suicidal Thoughts and Actions. Lorazepam may cause suicidal thoughts or actions in a small number of people. If you are about to harm yourself, call 911 or call or text 988, the Suicide & Crisis Lifeline. Call your healthcare provider right away if you have any of the following symptoms.
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New or increased thoughts of suicide or death
Suicide attempt
New or increased feelings of anxiety, depression, or other unusual changes in mood or behavior
Risk of Misuse and Addiction. Misusing lorazepam can lead to serious side effects like coma or death. Misuse means taking a medicine in a way other than how it was prescribed. Use lorazepam exactly as prescribed. Tell your healthcare provider if you feel that lorazepam is not working. Call your healthcare provider right away or go to the nearest emergency room if you experience any of the following serious symptoms.
Sudden confusion or feeling disoriented
Feeling paranoid
Suicidal thoughts or actions
Seizures
Trouble breathing
Dependence and Withdrawal Reactions. Lorazepam can cause physical dependence, which means your body relies on the medicine to function properly. If you stop lorazepam suddenly, it could lead to withdrawal symptoms, which may be life-threatening. Do not stop taking lorazepam without talking with your healthcare provider. Your healthcare provider will tell you how to stop lorazepam to reduce the risk of withdrawal reactions. Call your healthcare provider right away or go to the nearest emergency room if you experience any of the following serious symptoms.
Unusual movements, responses, or expressions
Seizures
Sudden and severe mental or nervous system changes
Seeing or hearing things that others do not see or hear, also called hallucinations
An extreme increase in activity or talking
Losing touch with reality
Some people may experience the following symptoms of a withdrawal reaction that can last for several weeks to more than 12 months.
Anxiety
Trouble remembering, learning, or concentrating
Depression
Problems sleeping
Feeling like insects are crawling under the skin
Weakness
Shaking
Muscle twitching
Burning or prickling feeling in the hands, arms, legs, or feet
Ringing in the ears
Risk With Opioid Medicines. Taking lorazepam with an opioid medicine, such as codeine, morphine, and oxycodone, may lead to severe drowsiness, breathing problems, coma, and death. Get emergency help right away if you experience the following symptoms.
Slow or shallow breathing
Breathing stops (which may lead to the heart stopping)
Excessive sleepiness or trouble staying awake
Decreased Alertness or Coordination. Lorazepam can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination until you know how lorazepam affects you.
Breathing Problems. Lorazepam may cause slow or shallow breathing, especially if you have breathing problems from another condition or take other medicines that can slow your breathing. Tell your healthcare provider if you develop severe sleepiness or trouble breathing, especially when you start lorazepam or when your dose is increased. Get emergency help if you have any of the following symptoms.
Changes in the color of your skin, including bluish color to your lips and fingernails
Confusion
Shortness of breath
Feeling dizzy, lightheaded, or fainting
Changes in your heart rate or rhythm, such as a fast, slow, pounding or skipping heartbeat
Slow or shallow breathing
Excessive sleepiness or trouble staying awake
Warnings & Precautions
Who should not use lorazepam?
Allergies to Ingredients. People who are allergic to any of the following should not take lorazepam.
Lorazepam
Ativan
Loreev XR
Any other medicine known as a benzodiazepine
Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in the specific lorazepam products they stock.
Glaucoma. Do not use lorazepam if you have acute narrow-angle glaucoma. There are different types of glaucoma. If you do not know what type you have, talk with your healthcare provider before taking lorazepam.
What should I know about lorazepam before using it?
Do not take lorazepam unless it has been prescribed to you by a healthcare provider. Take it as prescribed.
Do not share lorazepam with other people, even if they have the same condition as you. It may harm them.
Keep lorazepam out of the reach of children. Lorazepam is a controlled substance because it can be misused or lead to dependence. Store lorazepam in a safe place to protect it from theft. It is illegal to sell or give away this medicine.
Lorazepam can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination until you know how lorazepam affects you.
Extended-Release Oral Capsules. Do not crush or chew lorazepam extended-release oral capsules. Swallow lorazepam extended-release oral capsules whole. If you cannot swallow the capsules whole, they may be opened and sprinkled on applesauce, followed by drinking water, making sure the swallow the entire contents of the capsule.
Oral Concentrate. Use the syringe that comes with your medicine to draw up your dose, then add the dose to a liquid such as water, juice or soda. Lorazepam oral concentrate can also be added to applesauce, pudding, or other semi-solid foods. Make sure to swallow the entire dose. A household spoon is not an accurate measuring device and may cause you to take the wrong dose. A patient instruction sheet is enclosed in your medicine container to show you how to use the oral syringe.
What should I tell my healthcare provider before using lorazepam?
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if lorazepam is right for you.
In particular, make sure that you discuss any of the following.
Mental Health Problems. Tell your healthcare provider about your recent and current mental health problems, especially if you have had depression, thoughts of suicide or dying, or have ever attempted suicide.
Substance Use Disorder. Lorazepam is a controlled substance and may be misused or lead to dependence. Tell your healthcare provider if you have a history of a drug or alcohol disorder.
Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.
Liver problems
Kidney problems
Lung disease or breathing problems, including asthma, chronic obstructive pulmonary disease (COPD), pneumonia, or respiratory insufficiency
Seizures or epilepsy
A certain eye condition called acute narrow-angle glaucoma
A sleep problem called sleep apnea syndrome
Other Medicines and Supplements. Lorazepam may interact with other medicines and supplements. Before using lorazepam, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.
Pregnancy. It is not known if or how lorazepam could affect pregnancy or harm an unborn baby. Taking lorazepam during the later stages of pregnancy can cause withdrawal and the following symptoms in newborns.
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Breathing problems
Sluggish
Low muscle tone
Jittery
Fussiness or irritability
Restlessness
Shaking
Excessive crying
Feeding problems
Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider will advise you if you should use lorazepam while you are pregnant or trying to get pregnant. If you become pregnant, talk to your healthcare provider about registering with the National Pregnancy Registry for Psychiatric Medications. This registry collects information about the safety of psychiatric medicines during pregnancy. You can register by calling 866-961-2388 or online at https://womensmentalhealth.org/pregnancyregistry/.
Breastfeeding. Lorazepam passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take lorazepam while breastfeeding.
Interactions
Does lorazepam interact with foods or drinks?
There are no known interactions between lorazepam and foods or drinks.
Do not drink alcohol while taking lorazepam. The risk of serious problems such as severe dizziness, sleepiness, and trouble breathing may be increased if you drink alcohol while taking lorazepam.
Does lorazepam interact with other medicines (drug interactions)?
Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
In particular, make sure to discuss if you are using any of the following before taking lorazepam.
An opioid, such as oxycodone, morphine, codeine, or fentanyl, which is a medicine used for certain types of pain
Any other medicine that causes dizziness and sleepiness, such as prescription pain medicines, sleep medicines, and medicines for anxiety
Flumazenil (Romazicon), which is a medicine used to manage benzodiazepine overdose
Valproic acid (Depakote), which is a medicine commonly used to treat bipolar disorder, seizures, or migraine headaches
Probenecid (Benemid), which is a medicine to treat gout
Clozapine (Clozaril), which is a medicine to treat schizophrenia
Theophylline (Theobid) and Aminophylline (Norphyl), which are medicines to treat asthma and other lung or breathing problems
Lorazepam interacts with many other medicines. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
This may not be a complete list of medicines that can interact with lorazepam. Always check with your healthcare provider.
Does Lorazepam (Ativan, Loreev XR) interact with other drugs you are taking?
Enter your medication into the WebMD interaction checker
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Overdose/Missed Dose
What should I do if I accidentally use too much lorazepam?
If you or someone else has used too much lorazepam, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
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